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| Immunohistology | ||
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Utilization of immunohistological methods allows our pathologists to evaluate tumors, renal biopsies, and skin biopsies. This standard of care is invaluable for the identification of ultrastructural changes that can be of diagnostic significance. Cellular phenotypes can be directly visualized via morphology. Slides remain permanently labeled, and can thus be stored for future use. Immunohistological methods can help pathologists establish cellular origins to poorly differentiated tumors, classify lymphomas and leukemias, detect micrometastases in tissue, identify and qualitatively estimate hormone receptor and prognostic marker distribution for tumor evaluation, and isolate viral or other infective agent antigens. These immunohistologic stains are available: Breast Panel
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Immunoperoxidase
and immunofluorescence tissue stains permit a more certain evaluation
of cell identity and function in order to diagnose disease. The
principle behind this biochemical technique lies in the interactions
between antigens found within the cell and the antibodies that bind
to these antigens. Tissue samples are incubated with a specific
antibody (Fluorescent labeled) with high affinity for a marker antigen
that could be present in the tissue. If the antigen in question
is present in the sample, then the marked antibody will bind, revealing
previously unseen morphologic and structural features of the tissue.
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